Tad A Holak Selected Research

ethyl 3- (2- ((tert- butylamino)- 1- (N- (4- chlorobenzyl)formamido)- 2- oxoethyl)- 6- chloro- 1H- indole- 2- carboxylate

3/2014

Discovery of highly potent p53-MDM2 antagonists and structural basis for anti-acute myeloid leukemia activities.

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Tad A Holak Research Topics

Disease

42	Neoplasms (Cancer) 04/2024 - 01/2002
3	Melanoma (Melanoma, Malignant) 12/2015 - 03/2003
2	Neoplasm Metastasis (Metastasis) 01/2018 - 11/2003
2	Cardiomyopathies (Cardiomyopathy) 11/2017 - 02/2013
1	Premature Aging 11/2022
1	Neurodegenerative Diseases (Neurodegenerative Disease) 11/2022
1	Hypercholesterolemia 11/2022
1	Osteosarcoma (Osteogenic Sarcoma) 01/2019
1	Breast Neoplasms (Breast Cancer) 08/2018
1	Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung) 12/2015
1	Leukemia 03/2014
1	Chronic Disease (Chronic Diseases) 01/2013
1	Obesity 01/2013
1	Carcinogenesis 09/2007
1	Myeloproliferative Disorders (Myeloproliferative Disorder) 06/2006
1	Retinoblastoma (Glioblastoma, Retinal) 11/2005

Drug/Important Bio-Agent (IBA)

20	Proteins (Proteins, Gene)FDA Link 11/2022 - 01/2002
6	AntibodiesIBA 12/2023 - 02/2014
6	Monoclonal AntibodiesIBA 01/2018 - 12/2015
4	Oncogene Proteins (Oncogene Protein)IBA 04/2017 - 06/2006
3	LigandsIBA 12/2023 - 02/2014
3	Peptides (Polypeptides)IBA 01/2023 - 11/2003
2	Immune Checkpoint ProteinsIBA 04/2024 - 01/2017
2	Programmed Cell Death 1 ReceptorIBA 12/2023 - 10/2021
2	DNA (Deoxyribonucleic Acid)IBA 07/2019 - 12/2006
2	Hyaluronic Acid (Hyaluronan)IBA 01/2019 - 01/2018
2	Proto-Oncogene Proteins c-mdm2IBA 10/2018 - 08/2008
2	Cyclin D1IBA 04/2018 - 04/2017
2	Phosphotransferases (Kinase)IBA 01/2013 - 01/2002
1	B7-H1 AntigenIBA 10/2021
1	Oxidoreductases (Dehydrogenase)IBA 10/2021
1	malic acid (malate)IBA 10/2021
1	CarbonIBA 10/2021
1	Immune Checkpoint InhibitorsIBA 10/2020
1	Nucleotide AptamersIBA 10/2020
1	Therapeutic UsesIBA 01/2019
1	Membrane Proteins (Integral Membrane Proteins)IBA 01/2019
1	Drug CombinationsIBA 01/2019
1	indoleIBA 01/2019
1	RG7388IBA 10/2018
1	Immunoglobulin FragmentsIBA 08/2018
1	Fibroblast Growth Factor 1 (FGF-1)IBA 08/2018
1	CyclinsIBA 04/2017
1	Deubiquitinating EnzymesIBA 04/2017
1	Tumor Suppressor Protein p53IBA 01/2017
1	Carboxylic AcidsIBA 03/2014
1	EstersIBA 03/2014
1	ethyl 3- (2- ((tert- butylamino)- 1- (N- (4- chlorobenzyl)formamido)- 2- oxoethyl)- 6- chloro- 1H- indole- 2- carboxylateIBA 03/2014
1	quercetagetinIBA 01/2013
1	Phosphatidylinositol 3-Kinase (1 Phosphatidylinositol 3 Kinase)IBA 01/2013
1	Staphylococcal Protein A (Protein A)IBA 01/2012
1	Complement System Proteins (Complement)IBA 10/2007
1	14-3-3 Proteins (14-3-3 Protein)IBA 12/2006
1	Tumor Suppressor Proteins (Proteins, Tumor Suppressor)IBA 11/2005
1	Fibronectins (Fibronectin)IBA 11/2003
1	Cyclin DIBA 01/2002

Therapy/Procedure

13	Therapeutics 05/2021 - 09/2005
9	Immunotherapy 04/2024 - 02/2014
1	Oral Administration 12/2023